Indications for PGD

Unexplained Infertility

The most probable cause of unexplained infertility or history of habitual miscarriage is a chromosome abnormality. The male OR female partner may be a carrier of a translocation or be an aneuploid mosaic.



Next : Advanced Maternal Age

 

• What is PGD
   
• Indications for PGD
  - Recurrent Miscarriage
  - Unsuccessful IVF Cycles (>2)
  - Unexplained Infertility
  - Advanced Maternal Age
  - Male Factor Infertility
  - History of Chromosomally Abnormal Child or Pregnancy
  - Family history of structural chromosomal condition
  - Family history of X-linked disease
  - Inherited genetic disorders
  

• How PGD is performed
  - Oocyte aspiration
  - Fertilization and Embryo Culture
  - Polar body removal and/or blastomere biopsy
  - Preimplantation Genetic - Diagnosis in blastomeres
  - Embryo transfer and implantation
   

• Genetic diseases that can be diagnosed by PGD
   

• PGD in Italy: 1PB Testing
  - PGD on polar bodies
  - Preconception genetic diagnosis
  - Technical description of the procedure
  - Mutation analysis
  - Limitations
  - Advantages
  - Ethical issues