PGD for highly penetrant adult disorders such as Alzheimer?s
or Huntington?s disease prevents the birth of a child who
will be healthy for many years, but who in her late 30s or
early 40s will experience the onset of progressive
neurological disease leading to an early death.
Although these indications do not involve diseases that
manifest themselves in infancy or childhood, the conditions
in question lead to substantial health problems for
offspring in their thirties or forties.
Avoiding the birth of
children with those conditions thus reflects the desire of
parents to have offspring with good prospects for an average
By being able to identify these genes through particular
"markers" associated with the gene, doctors will know which
individuals are more susceptible to late-onset disorders.
The extremely difficult life experience of families affected
by inherited Alzheimer's disease or any other catastrophic
late-onset disorder--being unable to help their family
members suffering from the disease and being afraid they
will soon develop the disease themselves--makes them
responsible for insuring that their children will not face
the same difficulties.
Our experience in PGD for Late-onset Disorders