Approximately one in 900 individuals has a Robertsonian translocation. It involves the joining of any two of the following chromosomes: 13, 14, 15, 21 or 22.

These chromosomes have a unique structure in that they are primarily made of a bottom half. This translocation results from fusion of two of these chromosomes such that the two bottoms are attached.

Individuals with a Roberstonian translocation have 45 chromosomes, instead of the normal 46, because the two chromosomes stuck together are counted as one.

The most common translocation involves chromosomes 13 and 14 and is seen in about 1 in 1300 persons.



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