PGD for late on-set disorders
indications for use of PGD are being extended as compared
with standard practice of prenatal genetic diagnosis through
CVS and amniocentesis.
One of the proposed uses of PGD is the identification of
embryos at risk for late-onset or adult-onset diseases such
as Alzheimer's disease and cancer predisposition.
The use of PGD in late-onset disorders is controversial and
has not been well-studied.
There is insufficient evidence in the published,
peer-reviewed, scientific literature to support the use of
PGD for late-onset disorders.
Furthermore, it is not considered the standard of care. The
role of PGD in identifying those embryos at risk for
late-onset disorders is not known at this time.