PGD Conditions - Site Map

• PGD for single gene disorders
  - Monogenic diseases
  - History and Experience
  - Preliminary workup
  - Genetic Analysis
  - Mutation detection
  - Establishing a diagnosis
  - Monogenic diseases that can be diagnosed
  - Our experience in PGD for SGD
  - Example of the strategy used
  • PGD for b-Thalassemia
  • PGD for myotonic dystrophy
  • PGD for Primary dystonia
  • PGD for Duchenne muscular dystrophy (DMD)
  • PGD for Congenital Adrenal Hyperplasia (CAH)
  - Issues Associated with PGD for SGD
  - Sending Samples
  - Guidelines for transport PGD
  
   
• PGD for HLA matching
  - Indications for preimplantation HLA matching
  - Diseases Treated with Stem Cells Transplantation
  • Standard Therapies
  • Therapies in Clinical Trials
  • Experimental Treatments
  - Preimplantation HLA matching procedure
  • Preliminary Analyses
  • Informativity testing on couples
  • Preclinical work-up
  • Genetic Testing
    • Multiplex PCR
    • The HLA complex
    • HLA haplotying
  - Example of PGD for HLA matching
  • b-thalassaemia + HLA
  • Wiskott-Aldrich syndrome + HLA
  • Diamond-Blackfan anemia + HLA
  - Reliability of diagnosis
  - Limitations
  - Ethical considerations
  - Our experience in PGD for HLA matching
  - Accuracy of PGD for HLA matching
   
• PGD for inherited predisposition to cancer
  - Inherited cancer susceptibility
  - High and Lower penetrance conditions
  - Options for affected families
  - PGD for inherited cancer
  - Ethical issues
  - Protocols available in our Centre
  - Our experience in PGD for cancer
   
• PGD for late on-set disorders
  - Late-onset Disorders
  - Treatment Value
  - Our experience in PGD for Late-onset Disorders
   
• PGD for Aneuploidy Screening (PGD-AS)
  - Chromosome Aneuploidy
  - Risk of Aneuploidy and maternal age
  - PGD-AS Procedure
  - Establishing a diagnosis
  - Accuracy and Interpretations
  - Advantages of PGD-AS Procedure
  - Issues associated with PGD
  - Our experience in PGD - AS
   
• PGD for Chromosome Translocation
  - Chromosome Translocation
  • Reciprocal Translocations
  • Robertsonian Translocations
  - PGD Procedure
  - Preliminary Analyses
  - Advantages of PGD for translocation
  - Issues associated with PGD for translocation
  - Our experience in PGD for translocations
   
• References