Indications for PGD

Male Factor Infertility

Approximately one-half of all infertility is caused by sperm abnormalities. Many sperm disorders are due to a chromosome abnormality such as aneuploidy or a structural chromosome abnormality.

Men carrying a balanced translocation chromosome are at risk of producing sperm with a structural chromosome abnormality.

Several studies have determined that approximately 3-8% of sperm from normal, fertile men are aneuploid and 27-74% of sperm from men with severe infertility are aneuploid.

Couples with infertility due to male factor, should consider chromosome analysis on the males sperm prior to IVF.



Next : History of Chromosomally Abnormal Child or Pregnancy

 

• What is PGD
   
• Indications for PGD
  - Recurrent Miscarriage
  - Unsuccessful IVF Cycles (>2)
  - Unexplained Infertility
  - Advanced Maternal Age
  - Male Factor Infertility
  - History of Chromosomally Abnormal Child or Pregnancy
  - Family history of structural chromosomal condition
  - Family history of X-linked disease
  - Inherited genetic disorders
  

• How PGD is performed
  - Oocyte aspiration
  - Fertilization and Embryo Culture
  - Polar body removal and/or blastomere biopsy
  - Preimplantation Genetic - Diagnosis in blastomeres
  - Embryo transfer and implantation
   

• Genetic diseases that can be diagnosed by PGD
   

• PGD in Italy: 1PB Testing
  - PGD on polar bodies
  - Preconception genetic diagnosis
  - Technical description of the procedure
  - Mutation analysis
  - Limitations
  - Advantages
  - Ethical issues