Indications for PGD
Advanced Maternal Age
Women of advanced maternal age (≥ 37) are at a higher risk
of producing aneuploid embryos, resulting in implantation
failure, a higher risk of miscarriage or the birth of a
child with a chromosome abnormality (e.g. Down syndrome).
This is due to the fact that all of the woman's eggs
are present at birth. Over time, the chromosomes within the
egg are less likely to divide properly, resulting in cells
with too many or too few chromosomes.
Aneuploidy is also
believed to be a major reason for the decrease of fertility
ge. Several studies have determined that approximately 70%
of embryos from women of advanced maternal age may be
For women aged 37 years and older undergoing IVF, PGD for
aneuploidy significantly improves pregnancy rates, reduces
miscarriage rates, and decreases the chance of a
chromosomally abnormal pregnancy if six or more embryos of
good quality are available for analysis.
Male Factor Infertility